王晓莉   博士，讲师，硕士生导师   

学术经历：     

2002-2006 江苏大学药学院，获药学学士学位

2006-2012 复旦大学，遗传工程国家重点实验室，硕博连读，医学分子遗传学专业，获遗传学博士学位

2012-2015 武汉大学，组合生物合成与新药发现教育部重点实验室，博士后。

 学术成果：  

    主持过中央高校青年教师自主科研项目一项，作为主要参与人参研重点国际（地区）合作研究计划一项，国家重点基础研究发展计划项目（973计划）一项，发表SCI论文9篇，其中第一作者论文4篇。  

研究方向：  

1. 利用基因编辑技术（CRISPR/Cas9）研究经典遗传学和表观遗传学因素在精子发生、精子形成、精子成熟和受精过程的分子调控机制。  

2. 细胞器之间的相互作用在精子发生过程中的生物学功能和分子机理研究。

已发表论文：  

(1) Xiaoli Wang, Yujiao Wen, Juan Dong, Congcong Cao, Shuiqiao Yuan*. Systematic in-depth proteomic analysis of mitochondria-associated endoplasmic reticulum membranes (MAM) in mouse and human testes. Proteomics. 2018 May 21:e1700478. doi: 10.1002/pmic.201700478.

(2) Xiaoli Wang，Han Li，Guolong Fu，Youheng Wei^*，Shi Chen^*. Testis Specific Serine/threonine protein Kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76. Scientific Reports. 2016, 6:22861. doi: 10.1038/srep22861.

(3) Xiaoli Wang^#, Youheng Wei^#，*, Guolong Fu^#, Hexige Saiyin, Gang Lin, Zhugang Wang, Shi Chen, Long Yu^*. Tssk4 is essential for maintaining the structural integrity of sperm flagellum. Molecular human reproduction, 2015, 21(2): 136-145.

(4) Xiaoli Wang, Youheng Wei^*, Guolong Fu, Long Yu^*. Testis specific serine/threonine protein kinase 4 (TSSK4) leads to cell apoptosis relying on its kinase activity. Journal of Huazhong University of Science and Technology [Medical Sciences], 2015, 35(2): 235-240.

(5) Congcong Cao, Yujiao Wen, Xiaoli Wang, Na Fang, Shuiqiao Yuan*, Xunbin Huang*. Testicular piRNA profile comparison between successful and unsuccessful micro-TESE retrieval in NOA patients. Journal of assisted reproduction and genetics. 2018 Feb 19. doi: 10.1007/s10815-018-1134-4.

(6) Congcong Cao^#, Yujiao Wen^#, Juan Dong, Xiaoli Wang, Weibing Qin, Xunbin Huang, Shuiqiao Yuan^*. Maternally expressed miR-379/miR-544 cluster is dispensable for testicular development and spermatogenesis in mice. Molecular reproduction and development, 2018 Jan 16. doi: 10.1002/mrd.22957.

(7) Guolong Fu, Youheng Wei, Xiaoli Wang, Long Yu^*. Phosphorylated testis specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117. Bioscience, Biotechnology, and Biochemistry. 2016, 80(6):1088-1094.

(8) Shuo Liu, Yali Gao, Cheng Zhang, Han Li, Shiyi Pan, Xiaoli Wang, Shiming Du, Zixin Deng, Lianrong Wang, Zhiyin Song, Shi Chen^*. SAMM50 affects mitochondrial morphology through the association of Drp1 in mammalian cells. FEBS letter. 2016, 590 (9):1313-1323.

(9) Youheng Wei, Xiaoli Wang, Guolong Fu, Long Yu^*. Testis specific serine/threonine kinase 4 (Tssk4) maintains its kinase activity by phosphorylating itself at Thr-197. Molecular biology reports, 2013, 40(1): 439-447.

所在课题组网站：www.sqyuan-lab.com

电子邮箱：wangxiaoli@hust.edu.cn